Steven M Holland Selected Research

STAT1 Transcription Factor

1/2021	Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.
1/2018	Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations.
1/2017	Autoimmune Regulator Deficiency Results in a Decrease in STAT1 Levels in Human Monocytes.
4/2016	Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature.
7/2014	Gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation-related primary immunodeficiency is associated with disseminated mucormycosis.
6/2013	Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis.
9/2002	White blood cell defects: molecular discoveries and clinical management.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Steven M Holland Research Topics

Disease

107	Infections 05/2024 - 05/2002
52	Chronic Granulomatous Disease 12/2023 - 03/2002
27	Job Syndrome (Hyper-IgE Syndrome) 10/2020 - 12/2004
21	Neoplasms (Cancer) 05/2024 - 02/2004
21	Pneumonia (Pneumonitis) 01/2023 - 02/2004
17	Inflammation (Inflammations) 03/2024 - 03/2002
17	GATA2 Deficiency 10/2023 - 09/2011
16	Mycoses (Diseases, Fungus) 03/2024 - 06/2003
15	COVID-19 03/2024 - 10/2020
14	Eczema 09/2017 - 01/2004
11	Reinfection 09/2017 - 03/2003
8	Pulmonary Alveolar Proteinosis 10/2022 - 02/2010
8	Virus Diseases (Viral Diseases) 01/2022 - 11/2009
8	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2021 - 12/2010
7	Opportunistic Infections (Opportunistic Infection) 03/2024 - 12/2010
7	Neutropenia 01/2024 - 12/2009
7	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2023 - 03/2010
7	Coccidioidomycosis 01/2021 - 09/2009
7	Primary Immunodeficiency Diseases 01/2020 - 05/2008
7	Tuberculosis (Tuberculoses) 01/2019 - 04/2006
6	Lymphopenia (Lymphocytopenia) 01/2024 - 01/2012
6	Immune System Diseases (Immune Disorders) 01/2024 - 09/2002
6	Bacterial Infections (Bacterial Infection) 01/2024 - 06/2003
6	Eosinophilia 05/2018 - 01/2004
6	Abscess 01/2018 - 12/2004
6	Colitis 01/2017 - 12/2010
5	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 01/2023 - 08/2016
5	Cryptococcosis 10/2022 - 03/2014
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 02/2014
5	Disease Progression 01/2022 - 12/2009
5	Chronic Mucocutaneous Candidiasis 01/2022 - 08/2010
5	Exanthema (Rash) 01/2012 - 06/2003
5	Scoliosis 05/2009 - 11/2005
4	Lung Diseases (Lung Disease) 05/2024 - 10/2006
4	Aspergillosis 05/2024 - 04/2004
4	Thymoma (Thymic Carcinoma) 03/2024 - 12/2010
4	Periodontitis 03/2024 - 03/2014
4	Lymphadenopathy 10/2023 - 04/2004
4	Bronchiectasis 01/2023 - 12/2008
4	Nocardia Infections 10/2022 - 08/2002
4	Cryptococcal Meningitis 10/2022 - 08/2012
4	Cytopenia 01/2022 - 02/2010
4	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 02/2014
4	type 1 Autoimmune polyendocrinopathy syndrome 01/2021 - 12/2010
4	Inborn Genetic Diseases (Disease, Hereditary) 09/2017 - 01/2007
4	Hypertension (High Blood Pressure) 12/2014 - 10/2002
4	Autoimmune Diseases (Autoimmune Disease) 12/2013 - 02/2004
4	Dermatitis 01/2012 - 03/2004
3	Anaphylaxis (Anaphylactic Shock) 03/2024 - 12/2013
3	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2024 - 11/2010
3	Lymphoma (Lymphomas) 01/2023 - 12/2004
3	Candidiasis (Moniliasis) 01/2022 - 12/2010

Drug/Important Bio-Agent (IBA)

45	AutoantibodiesIBA 03/2024 - 10/2005
32	Immunoglobulin E (IgE)IBA 10/2020 - 01/2004
28	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022 - 03/2002
22	CytokinesIBA 09/2023 - 02/2006
21	InterferonsIBA 12/2023 - 08/2005
17	Interferon-gamma (Interferon, gamma)IBA 01/2024 - 08/2002
17	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2023 - 04/2003
16	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2004
15	Anti-Bacterial Agents (Antibiotics)IBA 05/2024 - 03/2003
15	Interleukin-12 (IL 12)IBA 03/2024 - 09/2002
13	Superoxides (Superoxide)IBA 01/2024 - 03/2002
13	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 04/2016 - 03/2002
11	NADP (NADPH)IBA 12/2023 - 03/2011
11	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/2022 - 02/2010
10	AntibodiesIBA 01/2024 - 12/2010
10	Oxidoreductases (Dehydrogenase)IBA 12/2023 - 10/2003
8	Immunoglobulin G (IgG)IBA 10/2023 - 06/2008
7	Biomarkers (Surrogate Marker)IBA 03/2024 - 02/2006
7	Immunoglobulins (Immunoglobulin)IBA 01/2024 - 02/2010
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 10/2003
7	STAT1 Transcription FactorIBA 01/2021 - 09/2002
7	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2018 - 12/2008
6	Messenger RNA (mRNA)IBA 03/2024 - 01/2017
6	VaccinesIBA 03/2024 - 04/2014
6	AntigensIBA 03/2024 - 04/2008
6	Oxidants (Oxidizing Agents)IBA 01/2022 - 03/2002
6	GATA2 Transcription FactorIBA 01/2022 - 04/2013
5	Interleukin-23 (Interleukin 23)IBA 03/2024 - 03/2014
5	Amphotericin B (Amphotericin)FDA LinkGeneric 01/2022 - 02/2006
5	Busulfan (Busulfex)FDA Link 01/2022 - 12/2014
5	Interferon gamma ReceptorIBA 08/2013 - 09/2004
4	Interferon Type IIBA 12/2023 - 01/2021
4	NF-kappa B (NF-kB)IBA 01/2016 - 02/2004
4	Matrix Metalloproteinases (MMPs)IBA 09/2015 - 06/2003
4	EnzymesIBA 01/2015 - 04/2003
4	DNA (Deoxyribonucleic Acid)IBA 07/2013 - 04/2004
3	LactamsIBA 05/2024 - 10/2021
3	mRNA VaccinesIBA 03/2024 - 11/2021
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2022 - 01/2020
3	interleukin-21 (interleukin 21)IBA 01/2022 - 07/2014

Therapy/Procedure

36	Therapeutics 05/2024 - 03/2003
15	Transplantation 11/2022 - 05/2004
13	Hematopoietic Stem Cell Transplantation 01/2022 - 06/2011
6	Immunotherapy 01/2023 - 02/2006
5	Cell Transplantation 04/2022 - 07/2019
5	Stem Cell Transplantation 01/2022 - 10/2003
5	Drug Therapy (Chemotherapy) 01/2017 - 12/2004
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/2020 - 02/2015